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Hildy Sanders
Professor of Biology
Office: KH 120A
Phone: 443-334-2303
Email: hsanders@stevenson.edu
Courses Taught
Biochemistry, Senior Research Seminar, Independent Laboratory Research in Biology, Foundations of Chemistry and Biology, Human Biology, Microbiology, General Biology I, General Biology II, The Human Body and Contemporary Health Issues
Education
Visiting Faculty, Johns Hopkins University Bloomberg School of Public Health, Department of Medical Microbiology and Immunity
Visiting Scientist, Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
Postdoctoral Fellow, Johns Hopkins University School of Medicine, Department of Physiological Chemistry
Ph.D., Johns Hopkins University, Department of Biology & McCollum-Pratt Institute, Biochemistry
A.B., Rutgers University, Newark College of Arts & Sciences, Biology
Research Interests
Gene Expression
My research students are using DNA microarrays to investigate differences in gene expression under different growth conditions in wild-type and mutant strains of yeast. Microarrays can show differences in expression of thousands of genes on a single slide or chip. Statistical analyses are then used to determine the significance of the differences in gene expression that appear on the chips. Students majoring in biology, chemistry and applied mathematics have worked on this project. During my sabbatical leave in the spring of 2008, I learned to use several types of software to analyze data from microarray experiments.
Mitochondrial Biogenesis
How do mitochondria, the cellular organelles responsible for supplying most of the energy cells, form? The question is interesting because:
- mitochondria contain their own genes (DNA) as well as the means to decode these genes, but
- most of the components of the mitochondria are manufactured outside the mitochondria, from DNA codes on genes in the nucleus; however,
- each mitochondrion is surrounded by two memberanes.
How do large moledules, such as proteins, that are manufactured outside the mitochondrion, get into and through this double membrane and to their specific destination within the mitochondrion? This is a question I studied during my sabbatical in the spring of 2000.
Cytochrome c structure and function
Cytochrome c is a heme protein in mitochondria necessary for the conversion of nutrient energy into ATP, the energy form needed by cells. It is one of the most studied proteins in terms of its variations in structure from one species to another and also the way that its structure affects its function.
Awards and Affiliations
National Science Foundation Predoctoral Fellow, 1963 – 1964
American Association for the Advancement of Science
Maryland Branch, American Society for Microbiology
National Science Teachers Association
ORD NIH Seed Grant “Gene Expression Studies of Hexose Metabolism”
Other Interests
International Folk Dancing
Baltimore International Folk Dancing
Meets Saturdays from 7:30 – 10:30 p.m.
Learn Dances from 7:30 – 8:30 p.m.
No partner necessary
For location and other information, contact Hildy Sanders at hsanders@stevenson.edu or 443-334-2303.
Travel
Icebergs from Portage Glacier in Portage Lake, Alaska
Genealogy
From generation to generation
Cats
